Here is the Snapshot of biggest Mergers & Acquisitions in Global Pharmaceutical industry. The ranking is as per the value of deal.

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Rank Year Purchaser Invested in Merger/Acquisition Value of deal (In USD Billion)
1 1999  Pfizer  Warner-Lambert Acquisition 111.8
2 2000  Glaxo Wellcome Plc  SmithKline Beecham Plc. Merger 76.0
3 2004  Sanofi  Aventis Acquisition 73.5
4 2015  Actavis  Allergan, Inc Acquisition 70.5
5 2009  Pfizer  Wyeth Acquisition 68.0
6 2016  Bayer  Monsanto Acquisition 66.0
7 2002  Pfizer  Pharmacia Acquisition 64.3
8 2009  Merck & Co.  Schering-Plough Acquisition 47.1
9 2014  Roche  Genentech Acquisition 44.0
10 2014 Medtronic  Covidien Acquisition 42.3
11 2015  Teva Pharmaceutical Industries  Actavis Business Unit 40.5
12 2010  Novartis  Alcon Acquisition 39.3
13 2016  Shire  Baxalta Acquisition Unit 32.0
14 2016  Abbott Laboratories  St Jude Medical Acquisition 30.5
15 1998  Astra AB  Zeneca Merger 30.4
16 2017  Johnson & Johnson  Actelion Acquisition 30.0
17 1998  Ciba-Geigy  Sandoz Merger (formed Novartis) 29.0
18 1999  Pharmacia & Upjohn  Monsanto Merger 25.2
19 2015  AbbVie  Pharmacyclics Acquisition 21.0
20 2014  Actavis  Forest Laboratories Acquisition 20.7
21 2011  Sanofi  Genzyme Corporation Acquisition 20.1
22 2012  Johnson & Johnson  Synthes Acquisition 19.7
23 2006  Bayer  Schering Acquisition 18.4
24 2016  Quintiles  IMS Health Merger (formed QuintilesIMS) 17.6
25 2001  Pfizer  Hospira Acquisition 17.0
26 2014  Merck Group  Sigma-Aldrich Acquisition 17.0
27 2001  Amgen  Immunex Acquisition 16.8
28 2006  Johnson & Johnson  Pfizer Consumer Health Business Unit 16.6
29 2014  Novartis  GlaxoSmithKline Oncology Business Unit 16.0
30 2015  Valeant  Salix Pharmaceuticals Acquisition 15.8
31 2007  AstraZeneca  MedImmune Acquisition 14.7
32 2007  Schering Plough  Organon International Acquisition 14.5
33 2014  Glaxo  Wellcome Acquisition 14.2
34 2014  Bayer  Merck & Co Consumer Health Business Unit 14.2
35 2006  Merck Group  Serono Acquisition 13.2
36 2016  Boehringer Ingelheim  Sanofi Animal Health (Merial) Business Unit 12.4
37 2017  Gilead Sciences  Kite Pharma Acquisition 11.9
38 2011  Gilead Sciences  Pharmasset Acquisition 11.2
39 2013  Amgen  Onyx Pharmaceuticals Acquisition 10.4

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